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Mouse cells advance arthritis research

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Osteoarthritis – the most common form of
arthritis in the United States – is a debilitating disease.Custom imprint usb
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shock-absorbing cartilage that prevents our bones from grinding against each
other; it causes pain, swelling and loss of mobility.

replacements, anti inflammatory drugs and even weight loss can help alleviate
symptoms, but a long-term cure is not available.

According to the Mayo
Clinic, osteoarthritis already affects more than 70 percent of adults between
the ages of 55 and 78. Any medical intervention that could replace damaged
cartilage or halt cartilage breakdown would be invaluable for treating this
expanding group of patients.

A new study from Duke, involving stem-cell
research, may be the first step in the development of such treatments.

In a paper published in October in the Proceedings of the National
Academy of Sciences, a team led by Farshid Guilak, professor of orthopedic
surgery and biomedical engineering at Duke, was able to create cells that
produce healthy cartilage.

Using a technique pioneered by Nobel
Prize-winning scientists John Gurdon and Shinya Yamanaka, the Duke researchers
first transformed adult mouse cells into induced pluripotent stem cells. These
“iPSCs” are similar to embryonic stem cells, in that they can become any other
cell type in the body.

The researchers were able to chemically instruct
the iPSCs to become the cells that produce cartilage.

Eventually, it may
be possible to generate such cartilage-producing cells in humans.FXI first
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osteoarthritis patients.

“In theory, we could use virtually any adult
human cell to first generate iPSCs,” Guilak said.

“From there, the exact
combination of chemicals for forming cartilage-producing cells may differ from
those used on mice; however, we are fairly confident that a similar procedure
will work.he security purposes of Buy
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There are multiple
advantages to using iPSCs instead of embryonic stem cells. IPSCs are created
from adult cells and do not raise the ethical issue of taking cells from an
embryo. Additionally, Guilak notes, replacement cartilage tissue created from
iPSCs would not be rejected by a patient’s immune system, overcoming the main
hurdle of current cartilage replacement therapies.

“The beauty of using
iPSCs to make cartilage replacements is that the initial adult cells can be
derived from the patient, unlike embryonic stem cells. This minimizes the chance
of immunologic rejection of the cartilage replacement.”

To further their
work with osteoarthritis, Guilak and his colleagues intend to study how drugs
could potentially slow the disease, as well as the genetic characteristics of
those who suffer from it.

“The idea behind developing an osteoarthritis
drug is to prevent the breakdown of cartilage. It will be difficult for drugs to
regenerate cartilage,Microsoft
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power users, but they could stop its degradation, which would provide a means of
preventing disease progression,” Guilak said.

“Our future studies will
focus on the development of human iPSCs from a range of people with and without
osteoarthritis, and on the genetic characteristics that predispose their
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