RDS (Respiratory Distress Syndrome) is the chief concern when fetal maturity tests get carried out. This is big issue that many doctor associate with infant mortality, most of them when they are in their full terms, and a distress in premature births. The development of lungs is important for premature babies. RDS arises as a result of the lungs not having enough surfactant; hence, they will not expand and even develop after the baby is born. This is because the alveoli in the lungs are not lowers resulting to hyaline membrane disease and ultimately the death of the baby.
Gluck’s two-dimensional thin layer chromatographic procedure has played the lead role in documenting fetal maturity. It has open windows to addressing the complication of infant mortality due to RDS. The procedure called the lecithin-sphingomyelin ration (L/S ratio) is renowned in analyzing lung maturity of the unborn baby. The admission of the L/S ratio procedure has values that are divided into 3 fetal maturity categories. These are the immature, transitional and mature values; each of the 3 is a phase in the development process. However, the procedure lacks distinctive differentiation markers to clearlyidentify each of the 3 categories. Hence, results from the L/S ration procedure need a careful interpretation to clearly document the correct fetal lung maturity stage.
Fetal-Tek 200 Fetal Maturity Test
With modern technology, things are now simpler to document when Fetal Maturity tests are of concern. Introducing the Fetal-Tek 200; it uses a one-dimensional TLC technique. The Fetal-Tek 200 technique separates lecithin and sphingomyelin commonly referred to in the L/S ration procedure. A mixture of water, methanol, 2-propanol, chloroform, and triethylamine is used as a stimulusfor the separation process done on TLC plate band. The process will separate the neutral lipids and phospholipids from the L/S, and then separate the L/S into lecithin and sphingomyelin. The final step in using the Fetal-Tek 200 for fetal maturity tests still observes the use of the L/S ration, which is determined by a scanning densitometer.
About the Author:
Fetal Maturity - Helena Laboratories is a clinical laboratory instrument and reagent manufacturer. Our clients include major medical centers, small hospitals, large reference laboratories and small private doctor's laboratories.
Fetal Maturity and the RDS (Respiratory Distress Syndrome) T