Large-scale DNA extraction and amplification projects require a large number of precise, small-volume dispensing actions. In assisting one of the biggest genomics initiatives ever, the Canadian Centre for DNA Barcoding (CCDB) has established high-volume workflows on the Rainin Liquidator 96 manual liquid handling system due to its precision, speed and ease of use.
As part of the International Barcode of Life Project, the largest biodiversity genomics initiative ever undertaken, the Canadian Centre for DNA Barcoding (CCDB) has chosen METTLER TOLEDO and its Rainin Liquidator 96 to fulfill fundamental roles in numerous liquid handling procedures required to process DNA samples. Manual control of aspiration and dispensing, as well as the instrument's flexible working platforms, helps the lab achieve the precision and processing speed it requires.
"The Liquidator 96 system allows you to control the pipetting speed for slow aspiration and dispensing. You can also change volumes in a single motion and move to the next step without interruption. This prevents the introduction of air bubbles and contamination," said Dr. Natalia Ivanova, lead DNA scientist, CCDB. Avoiding rework is critical, because the CCDB processes about 300,000 samples per year from animal, plant and fungal sources following a typical DNA extraction and PCR amplification workflow.
Between twenty and forty 96-well sample plates per day are handled using the Liquidator 96. The Liquidator is used for DNA extraction, DNA amplification using polymerase chain reaction (PCR) cycle sequencing, PCR reaction set up and cycle sequencing product cleanup.
Four working platforms allow easy movement between samples in process. To see a free, four-part video series on the use of Liquidator 96 by the CCDB and see how this manual system is significantly enhancing sensitive genomics workflow throughput, visit http://us.mt.com/us/en/home/supportive_content/specific_overviews/LIQ96_CCDB.html?crel=ePR_PP_EN
For more on how Liquidator 96 can generally enhance biotech processes, visit http://us.mt.com/us/en/home/products/level1_pipettes/Rainin_Pipettes/Liquidator96.html?als=liquidator96?crel=ePR_PP_EN
About Mettler Toledo:
METTLER TOLEDO specializes in the area of precision instruments for professional use. METTLER TOLEDO laboratory instruments are used in research, scientific, drug discovery, and quality control labs, amongst many others in the pharmaceutical, chemical, food and cosmetics industries. METTLER TOLEDO comprehensive industrial solutions cover the various steps in a host of manufacturing processes at many of the same customers that laboratory serves. Solutions range from receiving raw materials through various manufacturing processes, in-line process control and end-of-line packaging control, to logistics and shipping. Increasingly, these solutions are fully integrated into the customer's IT environment, helping automate their workflows. In food retail, our offering for fresh food management ranges from receiving and pre-packaging, to in-store solutions for self-service departments, deli counters, and checkout terminals.
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High throughput Manual Pipetting System Play KeyGenomic Role